2-Bromoethanol Property

Melting point:

-80 °C

Boiling point:

56-57 °C/20 mmHg (lit.)

Density 

1.763 g/mL at 25 °C (lit.)

vapor density 

4.3 (vs air)

vapor pressure 

2.4 mm Hg ( 20 °C)

refractive index 

n20/D 1.492(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

1-5 g/100 mL at 19°C

form 

Liquid

pka

13.82±0.10(Predicted)

color 

Clear colorless to yellow

Specific Gravity

1.7629 (20/4℃)

Water Solubility 

1-5 g/100 mL at 19 ºC

Sensitive 

Light Sensitive

Merck 

14,3792

BRN 

878140

Stability:

Stable, but probably light sensitive. Hygroscopic. Incompatible with strong oxidizing agents. Flammable. Forms an azeotrope with water.

InChIKey

LDLCZOVUSADOIV-UHFFFAOYSA-N

CAS DataBase Reference

540-51-2(CAS DataBase Reference)

NIST Chemistry Reference

Ethanol, 2-bromo-(540-51-2)

EPA Substance Registry System

2-Bromoethanol (540-51-2)

Safety

Hazard Codes 

T,T+,Xn,F

Risk Statements 

23/24/25-34-40-36/37/38-26/27/28-10-67-65-48/20-38-11-63

Safety Statements 

26-36/37/39-45-28A-16-62-36/37

RIDADR 

UN 2922 8/PG 2

WGK Germany 

3

RTECS 

KJ8225000

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

II

HS Code 

29055900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-Bromoethanol Chemical Properties,Usage,Production

Toxicity

2-Bromoethanol can damage human body. The invasive ways of 2-bromoethanol include inhalation, ingestion and percutaneous absorption. 2-Bromoethanol has strong irritation to mucosa, upper respiratory tract, eyes and skin. Inhalation of 2-bromoethanol can cause death due to spasm, inflammation and edema of larynx and bronchus, chemical pneumonia and pulmonary edema. The manifestations of 2-bromoethanol poisoning include burning sensation, cough, wheezing, laryngitis, shortness of breath, headache, nausea and vomiting.

Chemical Properties

2-Bromoethanol is a colorless or light yellow hygroscopic liquid with relatively stable and toxic chemical properties. It plays a role in industrial and chemical experiments. It shall be stored in a ventilated, low-temperature and dry warehouse and separated from oxidants, acids and food additives. It is miscible with water and forms an azeotrope with water. The boiling point is 99.1 ℃ (101.35kpa). The aqueous solution has a sweet burning taste. It can be miscible with most organic solvents such as ethanol and ether, but insoluble in petroleum ether. The hydrolysis of aqueous solution can be accelerated when it meets acid, alkali and heating.

Chemical Properties

colourless liquid

Uses

2-Bromoethanol is used in selective reduction of nitroarenes (PcFe(II)/NaBH4/2-bromoethanol catalyst system).

Uses

Ethylene bromohydrin is not used much forany commercial purpose. The risk of expo sure to this compound arises when ethyleneoxide reacts with hydrobromic acid.

Uses

2-Bromoethanol is utilized in selective reduction of nitroarenes. It is used as a solvent and organic synthetic raw material. It finds application in the synthesis of 2-piperidin-1-yl-ethanol by reacting with piperidine. It is used in selective reduction of nitroarenes.

General Description

Colorless to dark brown liquid. Sweet burning taste.

Air & Water Reactions

Hygroscopic. Water soluble.

Reactivity Profile

2-Bromoethanol forms an azeotrope with water; hydrolysis of aqueous solutions is accelerated by heat, alkalis and acids.

Hazard

Irritant to eyes and mucous membranes.

Health Hazard

The vapors of ethylene bromohydrin are anirritant to the eyes and mucous membranes.It is corrosive to the skin. Ingestion of thiscompound can produce moderate to severetoxic effects. The target organs are the CNS,gastrointestinal tract, and liver. The lethaldose in mice by the intraperitoneal route was80 mg/kg.
Ethylene bromohydrin manifested car cinogenicity in test animals. It caused tumorsin lungs and the gastrointestinal tract in micefrom intraperitoneal (150 mg/kg/8 weeks)and oral (43 mg/kg/80 weeks) dosages,respectively. It is a mutagen, positive to thehistidine reversion–Ames test.

Fire Hazard

2-Bromoethanol is combustible.

Safety Profile

Poison by intraperitoneal route. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Br-. See also

Waste Disposal

Ethylene bromohydrin is mixed with a combustible solvent and burned in a chemicalincinerator.